Ugh, I've seen all sorts of issues on Johnny Mnemonic with the glove disabled. For those who don't know, it locks balls on lock shots normally feeding the VUK, and starts modes in the Crazy Bob's hole. I played it that way for some time as I was trying to get the glove to work in PinMAME with a P-ROC board in place of the WPC controller. Was not successful since the emulated ROM couldn't cope with the additional P-ROC latency between driving the glove motors and getting rotary encoder feedback.
Anyway, in addition to losing a multiball due to a fast lock 3 to drain, I've also had a ball search during video mode end the ball prematurely. If playing with a disabled glove, I now make sure I'm hitting the flipper buttons often enough to avoid that outcome. I thought there were some other quirks, but it's been at least a year since I've played it that way.
And unlike Demolition Man where playing with the claw disabled is still quite fun, a disabled glove on JM means playing Video Mode as your first matrix award in every game, in addition to the other bugs you must deal with.